Iodine-containing Compounds of Extrathyroidal Tissues.
نویسندگان
چکیده
منابع مشابه
The effects of iodine deficiency on thyroid hormone deiodination.
Iodine deficiency induces multiple intrathyroidal autoregulatory changes leading to an increased triiodothyronine (T(3)) production and secretion, at the expense of thyroxine (T(4)). It is characterized by low serum T(4), normal or slightly elevated T(3), and as a consequence of the latter, normal thyrotropin (TSH). Tissues are also hypothyroxinemic, but their T(3) concentrations are mostly nor...
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Total body iodine content was estimated in six normal young men, who underwent 125I balance studies during 64-92 days of daily 125I administration. Total body retention of 125I was measured as the difference between total administered 125I and that collected in the urine and feces. Extrathyroidal 125I was the difference between total and thyroidal 125I content. The time-activity data for the ra...
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Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iod...
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The ability to concentrate iodide is a fundamental property of normally functioning thyroid tissue and represents the first step in the production of thyroid hormones. Iodide uptake has been demonstrated in various extrathyroidal tissues, including salivary gland, gastric mucosa, and lactating mammary gland. Recently, cloning and molecular characterization of the human sodium iodide symporter (...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 42 شماره
صفحات -
تاریخ انتشار 1963